Barcomb, Coultrap, Bayer: "Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B." dans: Molecular pharmacology, Vol. 84, Issue 6, pp. 834-43, (2013) (PubMed).
Antigène
Syntide-2
Sujet
The native peptide PLARTLSVAGLPGKK is a selective substrate for CaM kinase II and PKC. It is also a poor substrate for phosphorylase kinase and is not phosphorylated by myosin light chain kinase. The sequence of PLARTLSVAGLPGKK is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the peptide for different kinases are 100 for CaMK II, 22 for PKC, 2 for phosphorylase kinase, and 0.5 for myosin light chain kinase, respectively.