A synthetic peptide for use as a blocking control in assays to test for specificity of SPG20 antibody, Alternative Names: SPG20 control peptide, SPG20 antibody Blocking Peptide, Anti-SPG20 Blocking Peptide, Spastic Paraplegia 20 Blocking Peptide, Troyer Syndrome Blocking Peptide, KIAA0610 Blocking Peptide, SPARTIN Blocking Peptide, TAHCCP1 Blocking Peptide, SPG20, SPG-20, SPG 20, SPG-20 Blocking Peptide, SPG 20 Blocking Peptide
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified.