A synthetic peptide for use as a blocking control in assays to test for specificity of PCBP1 antibody, Alternative Names: PCBP1 control peptide, PCBP1 antibody Blocking Peptide, Anti-PCBP1 Blocking Peptide, Poly rC binding protein 1 Blocking Peptide, PCBP1, PCBP-1, PCBP 1, PCBP-1 Blocking Peptide, PCBP 1 Blocking Peptide
PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.