A synthetic peptide for use as a blocking control in assays to test for specificity of TIMELESS antibody, Alternative Names: TIMELESS control peptide, TIMELESS antibody Blocking Peptide, Anti-TIMELESS Blocking Peptide, timeless homolog, Drosophila Blocking Peptide
The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.