A synthetic peptide for use as a blocking control in assays to test for specificity of PML antibody, Alternative Names: PML control peptide, PML antibody Blocking Peptide, Anti-PML Blocking Peptide, promyelocytic leukemia Blocking Peptide, MYL Blocking Peptide, PP8675 Blocking Peptide, RNF71 Blocking Peptide, TRIM19 Blocking Peptide
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus.