Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-APP antibody (Catalog #: ARP33075_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Protein Interaction Partner: NAE1,TGFB1,TGFB2,APBA1,APP,HTRA2,PSEN1,PSEN1,PSEN1,PSEN2,APBA1,MAPK8IP1,PSEN1,PSEN1,ABL1,ACHE,APBA1,APBA2,APBA3,APBB1,APBB2,APBB3,APOE,APPBP2,BACE1,BACE2,BCAP31,BGN,BLMH,CALR,CASP3,CASP4,CASP6,CASP8,CAV1,CDK5,CHRNA7,CLU,COL1A2,COL25A1,COL4A1,COL4A2,COL4A3,COL4A5,COL4A6,CRYAB,CTSD,DAB1,EPB41,F12,FBLN1,FLOT1,GAPDH,GPC1,GRB2,GSK3B,GSN,HADHB,HMOX2,HSD17B10,HSPG2,HTRA2,IDE,ITM2B,KAT5,KLC1,KNG1,LAMA1,LDLRAP1,LRP1,LRP1B,MAPK8IP1,MAPK8IP2,NAE1,NCSTN,NECAB3,NF1,NID1,NUMB,NUMBL,PIN1,PPID,PRSS2,PRSS3,PSEN1,PSEN2,SERPINA3,SHC1,SHC3,SNCA,SNCB,SPON1,TGFB1,TGFB2,TM2D1,TP53BP2,ACHE,APBA1,APBA2,APBA3,APBB1,APBB2,APBB3,APPBP2,Apbb1,Apbb1,BGN,BLMH,CALR,CAV1,CLSTN1,COL25A1,DAB1,DAB2,FBLN1,GSN,HGS,HSD17B10,KLC1,NAE1,NCSTN,SHC1,SNCA,SNCB