This is a synthetic peptide designed for use in combination with anti-E2F1 antibody (Catalog #: P100821_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The protein encoded by E2F1 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: E2F-1, RBBP3, RBP3, RBAP1
Protein Interaction Partner: E2F2,E2F4,RBL2,BARD1,BIRC5,BRCA1,CBX5,CCDC76,CCNA1,CCNA2,CDC25A,CDC6,CDK1,CDKN2A,CEBPD,CEBPE,CHEK1,CSDA,E2F1,EAPP,FHL2,GAB2,GAS2L1,HIST1H2AG,HIST1H2BJ,HIST2H4A,JMY,MAD2L1,MAD2L1,MDM4,MFAP1,MLH1,MSH2,MSH2,MT1G,MYBL2,MYC,NCOA3,PPP1R13B,PPP1R13B,PRR11,RAD51,RAD54L,RB1,RB1,RB1,RB1,RB1,RB1,RBL1,RBL2,RECQL,TFDP1,TP53BP2,TP53BP2,TP53INP1,TTK,TYMS,UXT,ARID3A,ATM,ATR,BRCA1,BRD2,CCNA1,CCNA2,CDK1,CDK3,CDK7,CDKN2A,CEBPE,CHEK2,CREBBP,CTDP1,CUL1,DDB2,E2F6,GTF2H1,KAT5,MDM4,MNAT1,NCOA3,NCOA6,NDN,NFKB1,NPDC1,PARP1,PHB,PURA,RB1,SERTAD2,SKP2,SP1,SP2,SP3,SP4,TFDP1,TFDP2,TOPBP1,TP53,TP53BP1,TRRAP,ARID3A,BRD2,CCNA1,CCNA2,CDK2,CDK7,CDT1,CREBBP,CUL1,DNMT1,FHL2,GSK3B,GTF2H1,HDAC1,MDM4,MGA,MYBL2,NCOA6,NDN,NDNL2,NFKB1,NPDC1,Nfkb1,PHB,PKIB,PURA,RB1,RBBP4,RBL1,RING1,RNF144A,SKP2,SP1,SP2,SP3,SP4,SPIB,Sp1,TEAD3,TFDP1,TFDP2,TOPBP1,TP53BP1,TRRAP,UBC