Junction Mediating and Regulatory Protein, P53 Cofactor (JMY) (N-Term) Peptide
JMY
Reactivité: Humain
Hôte: Synthetic
BP, WB
-
- Antigène Tous les produits JMY
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Protein Region
- N-Term
- Origine
- Humain
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- VFIVAWNEIE GKFAITCHNR TAQRQRSGSR EQAGARGGAE AGGAASDGSR
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-JMY Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Antigène
- JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
- Synonymes
- WHDC1L3 Peptide, junction mediating and regulatory protein, p53 cofactor Peptide, junction-mediating and regulatory protein Peptide, JMY Peptide, jmy Peptide, Jmy Peptide
- Sujet
-
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. JMY increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, JMY acts as a nucleation-promoting factor for both branched and unbranched actin filaments. JMY activates the Arp2/3 complex to induce branched actin filament networks. JMY also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. JMY contributes to cell motility by controlling actin dynamics. JMY may promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Alias Symbols: FLJ37870, MGC163496, WHDC1L3
Protein Interaction Partner: EP300,MDM2,E2F1,E2F2,E2F3,E2F4,EP300
Protein Size: 712 - Poids moléculaire
- 82 kDa
- ID gène
- 133746
- NCBI Accession
- NM_152405, NP_689618
- UniProt
- Q8N9B5
-
Vous êtes ici:
