NR2C1
(Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-NR2C1 antibody (Catalog #: ARP38287_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Conseil sur la manipulation
Avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
NR2C1
(Nuclear Receptor Subfamily 2, Group C, Member 1 (NR2C1))
Synonymes
TR2 Peptide, NR2C1 Peptide, dor2 Peptide, tr2-11 Peptide, xDOR2 Peptide, DKFZp468M0512 Peptide, si:dkey-183c16.2 Peptide, zgc:110672 Peptide, 4831444H07Rik Peptide, 80.3 Peptide, Eenr Peptide, Tr2-11 Peptide, Tr2 Peptide, Psg4 Peptide, TR2-11 Peptide, PSG9 Peptide, nr2c1 Peptide, nuclear receptor subfamily 2 group C member 1 Peptide, nuclear receptor subfamily 2 group C member 1 S homeolog Peptide, nuclear receptor subfamily 2, group C, member 1 Peptide, pregnancy specific beta-1-glycoprotein 4 Peptide, nuclear receptor subfamily 2 group C member 1 L homeolog Peptide, NR2C1 Peptide, nr2c1.S Peptide, nr2c1 Peptide, Nr2c1 Peptide, PSG4 Peptide, nr2c1.L Peptide
Sujet
The nuclear orphan receptors NR2C1 represses transcription and binds DNA as a homodimer. NR2C1 binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. NR2C1 may function as a negative modulator to suppress androgen receptor function in prostate cancer. NR2C1 may exert an important repressor in regulating ER activity in mammary glands. The nuclear orphan receptors TR2 (NR2C1) and TR4 form a heterodimer that binds to the epsilon and gamma globin promoter DR1 sites
Alias Symbols: TR2, TR2-11
Protein Interaction Partner: AR,ESR1,HDAC3,HDAC4,NR2C2,NRIP1,AR,ESR1,HDAC3,HDAC4