PARP11
(Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))
Protein Region
Middle Region
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-PARP11 antibody (Catalog #: ARP33767_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Conseil sur la manipulation
Avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
PARP11
(Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))
Synonymes
5330431N24Rik Peptide, AI851877 Peptide, ARTD11 Peptide, HIN1L Peptide, C12orf6 Peptide, parp11 Peptide, MGC82612 Peptide, PARP11 Peptide, RGD1561791 Peptide, poly (ADP-ribose) polymerase family, member 11 Peptide, poly(ADP-ribose) polymerase family member 11 Peptide, poly(ADP-ribose) polymerase family member 11 S homeolog Peptide, poly(ADP-ribose) polymerase family member 11 L homeolog Peptide, Parp11 Peptide, PARP11 Peptide, parp11.S Peptide, parp11.L Peptide, parp11 Peptide
Sujet
PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.
Alias Symbols: C12orf6, DKFZp779H0122
Protein Interaction Partner: GTPBP3,DCAF11,GTPBP3,LYZ,NUP98,OTUD4,RNF114