Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-PHB antibody (Catalog #: ARP32807_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
Alias Symbols: PHB1
Protein Interaction Partner: RAF1,SMARCA2,SMARCA4,ANXA2,E2F1,HDAC1,MAP3K10,NCOR1,RAF1,RB1,RBL1,RBL2,SIN3A,SMARCA2,SMARCA4,SUMO4,TP53,XPO1,ACTN1,ANXA2,BRE,E2F1,HDAC1,MYOD1,NCOR1,RAF1,RB1,RBL1,RBL2,SIN3A,SMARCA2,SMARCA4,TP53