This is a synthetic peptide designed for use in combination with anti-POLI Antibody(ARP52299_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Conseil sur la manipulation
Avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
POLI
(Polymerase (DNA Directed) iota (POLI))
Synonymes
poli Peptide, wu:fc27h11 Peptide, zgc:110185 Peptide, GB12093 Peptide, NV16187 Peptide, RAD30B Peptide, RAD3OB Peptide, Rad30b Peptide, DNA polymerase iota Peptide, polymerase (DNA directed) iota Peptide, polymerase (DNA directed), iota Peptide, POLI Peptide, poli Peptide, LOC551219 Peptide, AFUA_4G11140 Peptide, LOC5568276 Peptide, Pol-iota Peptide, Poli Peptide
Sujet
POLI is an error-prone DNA polymerase specifically involved in DNA repair.POLI plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.POLI favors Hoogsteen base-pairing in the active site.POLI inserts the correct base with high-fidelity opposite an adenosine template.POLI exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine.POLI may play a role in hypermutation of immunogobulin genes.POLI forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Alias Symbols: RAD30B, RAD3OB
Protein Interaction Partner: REV1,CALCOCO2,DAZAP2,DVL2,PCNA,POLH,REV1,RNF11,UBA52,UBB,CALCOCO2,DAZAP2,DVL2