Retinoblastoma 1 (RB1) (N-Term) Peptide
RB1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits Retinoblastoma 1 (RB1)
- Retinoblastoma 1 (RB1)
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-RB1 Antibody(ARP58065_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- Retinoblastoma 1 (RB1)
- Synonymes
- OSRC Peptide, RB Peptide, p105-Rb Peptide, pRb Peptide, pp110 Peptide, Rb Peptide, Rb-1 Peptide, P105-RB Peptide, PP110 Peptide, RB11 Peptide, zgc:154147 Peptide, RB transcriptional corepressor 1 Peptide, RB transcriptional corepressor like 1 Peptide, retinoblastoma 1 Peptide, RB1 Peptide, RBL1 Peptide, Rb1 Peptide, rb1 Peptide
- Sujet
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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Alias Symbols: OSRC, RB, pRb, pp110, p105-Rb
Protein Interaction Partner: AATF,ABL1,AR,ATF2,BDP1,BGLAP,BIRC5,BNC2,BRCA1,BRD2,BRD8,CASP10,CASP2,CASP3,CASP6,CASP7,CASP8,CASP9,CCND1,CDK2,CDK4,CDK6,CDK6,CDKN1A,CEBPD,CEBPE,DNMT1,E1A,E2F1,E2F1,E2F1,E2F1,E2F1,E2F1,E2F2,E2F2,E2F2,EID1,EID1,EPO,FRK,GNB2L1,GTF3C2,HDAC1,HDAC1,HIF1A,HMGB1,
Protein Size: 928 - Poids moléculaire
- 106 kDa
- ID gène
- 5925
- NCBI Accession
- NM_000321, NP_000312
- UniProt
- P06400
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