TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-TNFSF10 antibody (Catalog #: AVARP02040_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L
Protein Interaction Partner: CREBBP,HDAC1,HDAC2,HDAC3,HDAC4,HDAC5,HIST3H3,SP1,SP3,IER3,TNFRSF10B,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D,TNFRSF11B,TNFSF10,ACP5,C7orf64,TNFRSF10A,TNFRSF10B,TNFRSF10D,TNFSF10