This is a synthetic peptide designed for use in combination with anti-TRPC6 antibody (Catalog #: ARP35144_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Alias Symbols: FLJ11098, FLJ14863, FSGS2, TRP6
Protein Interaction Partner: MX1,FYN,ITPR3,MX1,ORAI1,SRC,TRPC3,TRPC6,TRPM2,FYN,ITPR1,ITPR3,SRC,TRPC1,TRPC2,TRPC3,TRPC4,TRPC5,TRPC6,TRPC7