This is a synthetic peptide designed for use in combination with anti-UBE2D2 antibody (Catalog #: ARP43007_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Alias Symbols: E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B
Protein Interaction Partner: CBL,AMFR,BTRC,CBL,CNOT4,DTX3L,NEDD4,NFKBIA,PJA1,PJA2,RNF11,RNF5,UBE2D2,AMFR,APC11,BARD1,BIRC3,BTRC,CBL,CDKN1B,DDX58,DTX3L,DZIP3,EPS15,FBXL3,FBXO4,FBXO7,FBXW2,ING4,NEDD4,OTUB1,PDZRN3,PJA1,PJA2,POLL,POLM,RAF1,RNF11,RNF2,STAM2,STUB1,TRIM5,UBA6,UBASH3B,UBE3A