This is a synthetic peptide designed for use in combination with anti-VASP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Alias Symbols: -
Protein Interaction Partner: APBB1IP,TES,ABI1,ACTA1,ACTG1,APBB1,APBB1IP,DMRTB1,ERMAP,FYB,GSN,LPP,NOL3,PFN1,PFN2,PLSCR1,PRKACA,PRKG1,SPTA1,TES,TRIM9,VASP,VCL,WAS,WWP2,XPO6,ZYX,APBB1,DMRTB1,DNMBP,FYB,NOL3,PFN1,PFN2,PLSCR1,PRPF40A,RAPH1,TES,TRIM9,VASP,VCL,WAS,WWP2,XPO6,ZYX