PHLPP1 Produits
(PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
Catégories
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011].
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Catégories PHLPP1 en vedette
PHLPP1 Anticorps
High quality antibodies with extensive validation data.
PHLPP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
N° du produit
ABIN6145573
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7130610
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6264947
Quantité
100 μL
Fiche technique
Fiche technique
PHLPP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6206653
Quantité
96 tests
Fiche technique
Fiche technique
PHLPP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
- (1)
N° du produit
ABIN2728848
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PHLPP1
: "RNA-binding Protein Trinucleotide repeat-containing 6A Regulates the Formation of Circular RNA 0006916, with Important Functions in Lung Cancer Cells." dans: Carcinogenesis, (2018) (PubMed).: "Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." dans: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "Interactome of the negative regulator of nuclear import BRCA1-binding protein 2." dans: Scientific reports, Vol. 5, pp. 9459, (2015) (PubMed).
: "Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1." dans: Science signaling, Vol. 6, Issue 267, pp. ra19, (2013) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." dans: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
: "mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells." dans: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6510-20, (2011) (PubMed).
: "Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein ..." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19777-88, (2011) (PubMed).
: "Cell-type-specific regulation of raft-associated Akt signaling." dans: Cell death & disease, Vol. 2, pp. e145, (2011) (PubMed).
: "IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects." dans: Endocrinology, Vol. 151, Issue 8, pp. 3752-63, (2010) (PubMed).
: "Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN ..." dans: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27900-10, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à PHLPP1
PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), PH domain and leucine rich repeat protein phosphatase 1 (phlpp1), PH domain and leucine rich repeat protein phosphatase 1 (Phlpp1), AI836256, mKIAA0606, PHLPP, Phlpp, PLEKHE1, Plekhe1, SCOP, ScopProtein level used designations for PHLPP1
- PH domain and leucine rich repeat protein phosphatase 1
- PH domain leucine-rich repeat-containing protein phosphatase 1-like
- PH domain leucine-rich repeat-containing protein phosphatase 1
- PH domain-containing family E member 1
- SCN circadian oscillatory protein
- pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
- suprachiasmatic nucleus circadian oscillatory protein
- pleckstrin homology domain-containing family E member 1
- Circadian Oscillatory Protein (SCOP)
- PH domain leucine-rich repeat protein phosphatase 1
- pleckstrin homology domain-containing family E protein 1
Avez-vous cherché autre chose?
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- PHLDA3
- PHLDA2
- PHLDA1
- PHKG2
- PHKG1
- PHKB
- PHKA2
- PHKA1
- PHIP
- PHGDH
- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHF23
- PHF21B
- PHLPP2
- PHNC2
- PHO85
- Phosducin
- Phosducin-Like
- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
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