PHLPP2 Produits
(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Catégories
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
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Catégories PHLPP2 en vedette
PHLPP2 Anticorps
High quality antibodies with extensive validation data.
PHLPP2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PHLPP2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
N° du produit
ABIN652395
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IHC (p), IP
Validations
- (2)
N° du produit
ABIN962593
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
N° du produit
ABIN392229
Quantité
400 μL
Fiche technique
Fiche technique
PHLPP2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6212123
Quantité
96 tests
Fiche technique
Fiche technique
PHLPP2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124383
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3094545
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3136302
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits PHLPP2
: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." dans: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." dans: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à PHLPP2
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S), PH domain and leucine rich repeat protein phosphatase 2 (phlpp2), PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), AI481772, C130044A18Rik, PHLPPL, phlppl, Phlppl, RGD1562857Protein level used designations for PHLPP2
- PH domain leucine-rich repeat-containing protein phosphatase 2
- PH domain and leucine rich repeat protein phosphatase 2
- PH domain leucine-rich repeat-containing protein phosphatase 2-like
- GTPase activating protein and VPS9 domains 1
Avez-vous cherché autre chose?
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- PHIP
- PHGR1
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- PHF8
- PHF7
- PHF6
- PHF5A
- PHF3
- PHNC2
- PHO85
- Phosducin
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- Phosphatase and Actin Regulator 3
- Phosphatase and Actin Regulator 4
- Phosphatase and Tensin Homolog
- Phosphate Cytidylyltransferase 1, Choline, alpha
- Phosphate Cytidylyltransferase 1, Choline, beta
- Phosphate-Binding Protein PstS 1
- Phosphatidylinositol Antibody IgG/IgM
- Phosphatidylinositol Binding clathrin Assembly Protein
- Phosphatidylinositol Phosphate
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, beta
- Phospho Protein Kinase C
- Phospho-Extracellular Signal-Regulated Kinase
- PHOSPHO1
- PHOSPHO2
- Phosphodiesterase
- Phosphodiesterase I
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