PI3K p85a/g/b anticorps (AA 465-469)
PI3K p85a/g/b
Reactivité: Humain, Souris, Rat
IHC
Hôte: Lapin
Polyclonal
unconjugated
(2 références)-
- Antigène
- PI3K p85a/g/b (Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
- Épitope
- AA 465-469
- Reactivité
- Humain, Souris, Rat
- Hôte
- Lapin
- Clonalité
- Polyclonal
- Application
- Immunohistochemistry (IHC)
- Specificité
- The antibody detects endogenous level of total PI3K P85 a/g/b protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Immunogène
- Peptide sequence around AA 465-469, 197-201, 462-466 (L-Y-E-E-Y) derived from Human PI3K P85. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotype
- IgG
-
- Indications d'application
- Immunohistochemistry: 1:50-1:100
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
-
-
: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." dans: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
: "The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells." dans: Lipids, Vol. 47, Issue 4, pp. 403-11, (2012) (PubMed).
-
: "Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells." dans: Lipids in health and disease, Vol. 12, pp. 83, (2013) (PubMed).
-
- Antigène
- PI3K p85a/g/b (Phosphoinositide 3 Kinase, p85 alpha/gamma/beta (PI3K p85a/g/b))
- Autre désignation
- PI3K P85 alpha/gamma/beta
- Sujet
- PI3K binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
- Poids moléculaire
- 85 kDa
- UniProt
- O00459
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