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PIAS4 Produits

(Protein Inhibitor of Activated STAT, 4 (PIAS4))

Catégories

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

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Catégories PIAS4 en vedette

PIAS4 Anticorps

High quality antibodies with extensive validation data.

PIAS4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PIAS4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (2)
N° du produit ABIN388061
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
N° du produit ABIN6264199
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
N° du produit ABIN388062
Quantité 400 μL
Fiche technique Fiche technique

PIAS4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1381423
Quantité 96 tests
Fiche technique Fiche technique

PIAS4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124650
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1314996
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7424143
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PIAS4

Alshareeda, Negm, Green, Nolan, Tighe, Albarakati, Sultana, Madhusudan, Ellis, Rakha: "SUMOylation proteins in breast cancer." dans: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).

Shima, Suzuki, Sun, Kono, Shi, Kinomura, Horikoshi, Ikura, Ikura, Kanaar, Igarashi, Saitoh, Kurumizaka, Tashiro: "Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage." dans: Journal of cell science, Vol. 126, Issue Pt 22, pp. 5284-92, (2013) (PubMed).

Fuhs, Insel: "Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization." dans: The Journal of biological chemistry, Vol. 286, Issue 17, pp. 14830-41, (2011) (PubMed).

Tong, Shen, Wang, Kan, Wang, Li, Wang, Yang, Guo: "DNA ploidy cytometry testing for cervical cancer screening in China (DNACIC Trial): a prospective randomized, controlled trial." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 20, pp. 6438-45, (2009) (PubMed).

La Salle, Sun, Zhang, Matunis, Handel: "Developmental control of sumoylation pathway proteins in mouse male germ cells." dans: Developmental biology, Vol. 321, Issue 1, pp. 227-37, (2008) (PubMed).

Brayman, Dharmaraj, Lagow, Carson: "MUC1 expression is repressed by protein inhibitor of activated signal transducer and activator of transcription-y." dans: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 11, pp. 2725-37, (2007) (PubMed).

Albor, El-Hizawi, Horn, Laederich, Frosk, Wrogemann, Kulesz-Martin et al.: "The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ..." dans: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25850-66, (2006) (PubMed).

Bischof, Schwamborn, Martin, Werner, Sustmann, Grosschedl, Dejean: "The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis." dans: Molecular cell, Vol. 22, Issue 6, pp. 783-94, (2006) (PubMed).

Ihara, Yamamoto, Kikuchi: "SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4." dans: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3506-18, (2005) (PubMed).

Zhang, Xu, Han, Wei, Shu: "PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis." dans: FEBS letters, Vol. 570, Issue 1-3, pp. 97-101, (2004) (PubMed).

Synonymes et noms alternatifs relatifs à PIAS4

protein inhibitor of activated STAT 4 (PIAS4), protein inhibitor of activated STAT, 4 (Pias4), protein inhibitor of activated STAT, 4a (pias4a), protein inhibitor of activated STAT 4 L homeolog (pias4.L), protein inhibitor of activated STAT 4 (pias4), protein inhibitor of activated STAT 4 (Pias4), protein inhibitor of activated STAT, 4b (pias4b), LOC100219439, Pias-gamma, pias4, pias4l, Piasg, piasg, PIASY, piasy, wu:fc54c11, wu:fi18c10, wu:fi20e09, wu:fi26h11, wu:fk93f11, zgc:63923, zgc:66410, ZMIZ6, zmiz6

Protein level used designations for PIAS4

  • E3 SUMO-protein ligase PIAS4
  • PIAS-gamma
  • protein inhibitor of activated STAT protein 4
  • protein inhibitor of activated STAT protein PIASy
  • protein inhibitor of activated STAT protein gamma
  • zinc finger, MIZ-type containing 6
  • protein inhibitor of activated STAT 4
  • protein inhibitor of activated STAT, 4
  • E3 SUMO-protein ligase PIAS4-like
  • e3 SUMO-protein ligase PIAS4-like
  • protein inhibitor of activated STAT PIASy
  • protein inhibitor of activated STAT, 4b
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