PIP5K1A Produits
(Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
Catégories
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
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Catégories PIP5K1A en vedette
PIP5K1A Anticorps
High quality antibodies with extensive validation data.
PIP5K1A Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PIP5K1A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (4)
N° du produit
ABIN948678
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7163185
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (2)
- (2)
N° du produit
ABIN392593
Quantité
400 μL
Fiche technique
Fiche technique
PIP5K1A recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6220514
Quantité
96 tests
Fiche technique
Fiche technique
PIP5K1A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315137
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315135
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509093
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PIP5K1A
: "Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module." dans: Nature immunology, Vol. 10, Issue 2, pp. 185-94, (2009) (PubMed).: "Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice." dans: Brain research. Molecular brain research, Vol. 134, Issue 2, pp. 239-55, (2005) (PubMed).
: "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling." dans: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 23036-45, (2003) (PubMed).
: "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization." dans: Cytogenetics and cell genetics, Vol. 88, Issue 3-4, pp. 197-9, (2000) (PubMed).
Synonymes et noms alternatifs relatifs à PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A), phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa), phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab), im:7140933, PIP5K1A, pip5k1a, Pip5k1b, pip5k1b, pip5k1c, Pipk5a, Pipk5b, zgc:110576, zgc:158838Protein level used designations for PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
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