PKC iota Produits
(Protein Kinase C, iota (PRKCI))
Catégories
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008].
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Catégories PKC iota en vedette
PKC iota Anticorps
High quality antibodies with extensive validation data.
PKC iota Kits ELISA
Reliable ELISA kits for a wide range of species.
PKC iota Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PKC iota recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7444109
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (5)
N° du produit
ABIN562391
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (3)
N° du produit
ABIN391010
Quantité
400 μL
Fiche technique
Fiche technique
PKC iota recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1116783
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1116784
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Validations
N° du produit
ABIN1057780
Quantité
96 tests
Fiche technique
Fiche technique
PKC iota recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (2)
N° du produit
ABIN1316270
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316272
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509106
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PKC iota
: "PKCiota promotes ovarian tumor progression through deregulation of cyclin E." dans: Oncogene, Vol. 35, Issue 19, pp. 2428-40, (2016) (PubMed).: "PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling." dans: Biochemical and biophysical research communications, Vol. 470, Issue 2, pp. 306-12, (2016) (PubMed).
: "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 308, Issue 9, pp. G745-56, (2015) (PubMed).
: "Par-complex aPKC and Par3 cross-talk with innate immunity NF-κB pathway in epithelial cells." dans: Biology open, Vol. 2, Issue 11, pp. 1264-9, (2013) (PubMed).
: "Significance and expression of atypical protein kinase C-iota in human hepatocellular carcinoma." dans: The Journal of surgical research, Vol. 154, Issue 1, pp. 143-9, (2009) (PubMed).
: "Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma." dans: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 7, Issue 1, pp. 70-5, (2008) (PubMed).
: "Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells." dans: Journal of cell science, Vol. 121, Issue Pt 5, pp. 644-54, (2008) (PubMed).
: "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota." dans: Cancer research, Vol. 68, Issue 18, pp. 7403-8, (2008) (PubMed).
: "Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms." dans: The Journal of biological chemistry, Vol. 281, Issue 44, pp. 33773-88, (2006) (PubMed).
: "Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway." dans: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22118-23, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à PKC iota
protein kinase C iota (PRKCI), protein kinase C, iota (prkci), protein kinase C, iota (Prkci), protein kinase C iota (Prkci), 2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkci, Pkcl, PKClambda, PRKCI, PrkclProtein level used designations for PKC iota
- PRKC-lambda/iota
- aPKC-lambda/iota
- atypical protein kinase C-lambda/iota
- protein kinase C iota type
- heart and soul protein
- nPKC-iota
- protein kinase C, iota
- protein kinase C iota
- protein kinase C, lambda
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