PKD1 Produits
(Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
Catégories
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].
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Catégories PKD1 en vedette
PKD1 Anticorps
High quality antibodies with extensive validation data.
PKD1 Kits ELISA
Reliable ELISA kits for a wide range of species.
PKD1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PKD1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7163832
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (4)
- (1)
N° du produit
ABIN678083
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC, WB
Validations
- (1)
N° du produit
ABIN3186481
Quantité
100 μL
Fiche technique
Fiche technique
PKD1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969448
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN6200495
Quantité
96 tests
Fiche technique
Fiche technique
PKD1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7505263
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PKD1
: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." dans: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." dans: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).
: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).
: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." dans: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).
Synonymes et noms alternatifs relatifs à PKD1
polycystin 1, transient receptor potential channel interacting (PKD1), polycystin 1, transient receptor poteintial channel interacting (Pkd1), polycystin 1, transient receptor potential channel interacting (Pkd1), polycystin-1 (LOC749291), mFLJ00285, PBP, Pc-1, PC1, TRPP1Protein level used designations for PKD1
- autosomal dominant polycystic kidney disease 1 protein
- polycystic kidney disease-associated protein
- polycystin 1
- polycystin-1
- transient receptor potential cation channel, subfamily P, member 1
- autosomal dominant polycystic kidney disease 1 protein homolog
- polycystic kidney disease 1 homolog; polycystin-1
- polycystic kidney disease 1 (autosomal dominant)
- polycystic kidney disease protein 1
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