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PLAU Produits

(Plasminogen Activator, Urokinase (PLAU))
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].

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Catégories PLAU en vedette

PLAU Anticorps

High quality antibodies with extensive validation data.

PLAU Kits ELISA

Reliable ELISA kits for a wide range of species.

PLAU Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PLAU recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, FACS, IHC (p)
Validations
  • (8)
  • (4)
N° du produit ABIN1882148
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (5)
N° du produit ABIN185470
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, FACS, IF
Validations
  • (6)
N° du produit ABIN3032244
Quantité 0.4 mL
Fiche technique Fiche technique

PLAU recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (8)
  • (1)
N° du produit ABIN6958612
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6958613
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6976235
Quantité 96 tests
Fiche technique Fiche technique

PLAU recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
N° du produit ABIN7275455
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275453
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7275460
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PLAU

Dreymann, Sabrowski, Danso, Menger: "Aptamer-Based Sandwich Assay Formats for Detection and Discrimination of Human High- and Low-Molecular-Weight uPA for Cancer Prognosis and Diagnosis." dans: Cancers, Vol. 14, Issue 21, (2022) (PubMed).

Tian, Chen, Zhang, Li, Wang, Han, Zhang, Fu, Li, Nie, Zhao, Tan, Wang, Guan, Hong: "Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma." dans: Oncotarget, Vol. 8, Issue 26, pp. 42300-42313, (2018) (PubMed).

Jia, Thelwell, Dilger, Bird, Daniels, Wadhwa: "Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy." dans: Thrombosis research, Vol. 163, pp. 105-116, (2018) (PubMed).

Wang, Jiang, An, Mao, Lin, Sun: "Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro." dans: Molecular medicine reports, Vol. 17, Issue 3, pp. 4273-4280, (2018) (PubMed).

Joseph, Tholanikunnel, Kaplan: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." dans: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).

Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." dans: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).

Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." dans: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

Shen, Chen, Gan, Hu, Zhong, Li, Xie, Liu, Li, Xu, Huang, Chen: "Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC." dans: Biochemical and biophysical research communications, Vol. 470, Issue 3, pp. 627-34, (2016) (PubMed).

Huang, Liu, Huang, Li, Gan, Shen: "1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway." dans: International journal of oncology, Vol. 48, Issue 3, pp. 1271-9, (2016) (PubMed).

Bi, Zeng, Zhao, Wei, Yu, Wang, Yu, Cao, Shan, Wei: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." dans: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, (2016) (PubMed).

Synonymes et noms alternatifs relatifs à PLAU

plasminogen activator, urokinase (PLAU), urokinase-type plasminogen activator (CpipJ_CPIJ002131), urokinase-type plasminogen activator (CpipJ_CPIJ006543), urokinase-type plasminogen activator (CpipJ_CPIJ013396), urokinase-type plasminogen activator (CpipJ_CPIJ013623), plasminogen activator, urokinase (Plau), ATF, BDPLT5, PLAU, QPD, u-PA, UPA, uPA, UPAM, URK

Protein level used designations for PLAU

  • urokinase-type plasminogen activator
  • U-plasminogen activator
  • uPA
  • plasminogen activator, urokinase
  • plasminogen activator, urinary
  • Urinary plasminogen activator, urokinase
  • urokinase plasminogen activator preproprotein
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