PLAU Produits
(Plasminogen Activator, Urokinase (PLAU))
Catégories
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
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Catégories PLAU en vedette
PLAU Anticorps
High quality antibodies with extensive validation data.
PLAU Kits ELISA
Reliable ELISA kits for a wide range of species.
PLAU Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PLAU recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (8)
- (4)
N° du produit
ABIN1882148
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (5)
N° du produit
ABIN185470
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, IF
Validations
- (6)
N° du produit
ABIN3032244
Quantité
0.4 mL
Fiche technique
Fiche technique
PLAU recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (1)
N° du produit
ABIN6958612
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6958613
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6976235
Quantité
96 tests
Fiche technique
Fiche technique
PLAU recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
N° du produit
ABIN7275455
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275453
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275460
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PLAU
: "Aptamer-Based Sandwich Assay Formats for Detection and Discrimination of Human High- and Low-Molecular-Weight uPA for Cancer Prognosis and Diagnosis." dans: Cancers, Vol. 14, Issue 21, (2022) (PubMed).: "Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma." dans: Oncotarget, Vol. 8, Issue 26, pp. 42300-42313, (2018) (PubMed).
: "Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy." dans: Thrombosis research, Vol. 163, pp. 105-116, (2018) (PubMed).
: "Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro." dans: Molecular medicine reports, Vol. 17, Issue 3, pp. 4273-4280, (2018) (PubMed).
: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." dans: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).
: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." dans: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).
: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." dans: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).
: "Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC." dans: Biochemical and biophysical research communications, Vol. 470, Issue 3, pp. 627-34, (2016) (PubMed).
: "1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway." dans: International journal of oncology, Vol. 48, Issue 3, pp. 1271-9, (2016) (PubMed).
: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." dans: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, (2016) (PubMed).
Synonymes et noms alternatifs relatifs à PLAU
plasminogen activator, urokinase (PLAU), urokinase-type plasminogen activator (CpipJ_CPIJ002131), urokinase-type plasminogen activator (CpipJ_CPIJ006543), urokinase-type plasminogen activator (CpipJ_CPIJ013396), urokinase-type plasminogen activator (CpipJ_CPIJ013623), plasminogen activator, urokinase (Plau), ATF, BDPLT5, PLAU, QPD, u-PA, UPA, uPA, UPAM, URKProtein level used designations for PLAU
- urokinase-type plasminogen activator
- U-plasminogen activator
- uPA
- plasminogen activator, urokinase
- plasminogen activator, urinary
- Urinary plasminogen activator, urokinase
- urokinase plasminogen activator preproprotein
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