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POLI Produits

(Polymerase (DNA Directed) iota (POLI))

Catégories

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).

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Catégories POLI en vedette

POLI Anticorps

High quality antibodies with extensive validation data.

POLI Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

POLI recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
  • (5)
N° du produit ABIN564869
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
N° du produit ABIN6264338
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7150251
Quantité 100 μg
Fiche technique Fiche technique

POLI recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6203766
Quantité 96 tests
Fiche technique Fiche technique

POLI recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124512
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315650
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315648
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits POLI

McIntyre, Sobolewska, Fedorowicz, McLenigan, Macias, Woodgate, Sledziewska-Gojska: "DNA polymerase ι is acetylated in response to SN2 alkylating agents." dans: Scientific reports, Vol. 9, Issue 1, pp. 4789, (2019) (PubMed).

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." dans: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Sekimoto, Oda, Kurashima, Hanaoka, Yamashita: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." dans: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).

Ziv, Zeisel, Mirlas-Neisberg, Swain, Nevo, Ben-Chetrit, Martelli, Rossi, Schiesser, Canman, Carell, Geacintov, Falini, Domany, Livneh: "Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin." dans: Nature communications, Vol. 5, pp. 5437, (2014) (PubMed).

Diamant, Hendel, Vered, Carell, Reissner, de Wind, Geacinov, Livneh: "DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity." dans: Nucleic acids research, Vol. 40, Issue 1, pp. 170-80, (2011) (PubMed).

Takezawa, Ishimi, Aiba, Yamada: "Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation." dans: Journal of nucleic acids, Vol. 2010, pp. 750296, (2010) (PubMed).

Ziv, Geacintov, Nakajima, Yasui, Livneh: "DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11552-7, (2009) (PubMed).

Wang, Woodgate, McManus, Mead, McCormick, Maher: "Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations." dans: Cancer research, Vol. 67, Issue 7, pp. 3018-26, (2007) (PubMed).

Choi, Besaratinia, Lee, Lee, Pfeifer: "The role of DNA polymerase iota in UV mutational spectra." dans: Mutation research, Vol. 599, Issue 1-2, pp. 58-65, (2006) (PubMed).

Frank, Tissier, McDonald, Rapi?-Otrin, Zeng, Gearhart, Woodgate: "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2914-22, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à POLI

DNA polymerase iota (POLI), polymerase (DNA directed) iota (poli), DNA polymerase iota (LOC551219), DNA polymerase iota (AFUA_4G11140), DNA polymerase iota (LOC5568276), polymerase (DNA directed) iota (Pol-iota), polymerase (DNA directed), iota (Poli), DNA polymerase iota (Poli), GB12093, NV16187, poli, RAD3OB, RAD30B, Rad30b, wu:fc27h11, zgc:110185

Protein level used designations for POLI

  • DNA polymerase iota
  • polymerase (DNA directed) iota
  • DNA polymerase iota-like
  • RAD30 homolog B
  • eta2
  • polymerase (DNA-directed), iota
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