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POT1 Produits

(Protection of Telomeres 1 (POT1))
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

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Catégories POT1 en vedette

POT1 Anticorps

High quality antibodies with extensive validation data.

POT1 Kits ELISA

Reliable ELISA kits for a wide range of species.

POT1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

POT1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7164998
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN565204
Quantité 50 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (2)
N° du produit ABIN5663924
Quantité 100 μL
Fiche technique Fiche technique

POT1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958904
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN4972163
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN5658187
Quantité 96 tests
Fiche technique Fiche technique

POT1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315766
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (1)
N° du produit ABIN2729370
Quantité 20 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7409542
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits POT1

Swanson, Baribault, Israel, Bae: "Telomere protein RAP1 levels are affected by cellular aging and oxidative stress." dans: Biomedical reports, Vol. 5, Issue 2, pp. 181-187, (2016) (PubMed).

Su, Cheng, Tzeng, Lin, Hsu: "An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).

Sishc, Nelson, McKenna, Battaglia, Herndon, Idate, Liber, Bailey: "Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis." dans: Frontiers in oncology, Vol. 5, pp. 257, (2015) (PubMed).

Luo, Feng, Wang, Xu, Zhao, Ma, Jiang, Liu, Huang, Songyang: "Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression." dans: Aging cell, Vol. 14, Issue 3, pp. 391-9, (2015) (PubMed).

Ci, Li, Ma, Kong, Zheng, Björkholm, Jia, Xu: "Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells." dans: Oncotarget, Vol. 6, Issue 35, pp. 38079-92, (2015) (PubMed).

Choi, Lakamp-Hawley, Kolar, Yan, Borgstahl, Ouellette: "The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs." dans: Biochimie, Vol. 115, pp. 17-27, (2015) (PubMed).

Wojdyla, Stone, Sethakorn, Uppada, Devito, Bissonnette, Puri: "T-oligo as an anticancer agent in colorectal cancer." dans: Biochemical and biophysical research communications, Vol. 446, Issue 2, pp. 596-601, (2014) (PubMed).

Robles-Espinoza, Harland, Ramsay, Aoude, Quesada, Ding, Pooley, Pritchard, Tiffen, Petljak, Palmer, Symmons, Johansson, Stark, Gartside, Snowden, Montgomery, Martin, Liu, Choi, Makowski, Brown et al.: "POT1 loss-of-function variants predispose to familial melanoma. ..." dans: Nature genetics, Vol. 46, Issue 5, pp. 478-81, (2014) (PubMed).

Jullien, Mestre, Roux, Gire: "Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response." dans: Nucleic acids research, Vol. 41, Issue 2, pp. 900-11, (2013) (PubMed).

Kamranvar, Chen, Masucci: "Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus." dans: Oncogene, Vol. 32, Issue 49, pp. 5522-30, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à POT1

protection of telomeres 1 (POT1), protection of telomeres 1 L homeolog (pot1.L), protection of telomeres 1A (Pot1a), protection of telomeres 1 (Pot1), 1500031H18Rik, AI851169, DKFZp469P1825, HPOT1, POT1, pot1, Pot1, Pot1a

Protein level used designations for POT1

  • POT1-like telomere end-binding protein
  • protection of telomeres 1 homolog
  • protection of telomeres protein 1
  • POT1 protection of telomeres 1 homolog
  • cPot1
  • single-strand telomeric DNA-binding protein
  • POT1 protection of telomeres 1 homolog (S. pombe)
  • protection of telomeres 1
  • protection of telomeres 1 homolog (S. pombe)
  • protection of telomeres protein 1-like
  • mPot1
  • protection of telomeres 1A
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