PPP4C Produits
(Protein Phosphatase 4, Catalytic Subunit (PPP4C))
Catégories
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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Catégories PPP4C en vedette
PPP4C Anticorps
High quality antibodies with extensive validation data.
PPP4C Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PPP4C recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP
Validations
- (9)
N° du produit
ABIN3022939
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN7260177
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (3)
N° du produit
ABIN669261
Quantité
100 μL
Fiche technique
Fiche technique
PPP4C recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969743
Quantité
96 tests
Fiche technique
Fiche technique
PPP4C recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316083
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316081
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2131274
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PPP4C
: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." dans: eLife, Vol. 3, pp. e01695, (2014) (PubMed).: "Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells." dans: Biochimica et biophysica acta, Vol. 1783, Issue 8, pp. 1490-502, (2008) (PubMed).
: "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation." dans: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26143-8, (2004) (PubMed).
: "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation." dans: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46588-94, (2004) (PubMed).
: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." dans: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à PPP4C
protein phosphatase 4 catalytic subunit (ppp4c), protein phosphatase 4, catalytic subunit a (ppp4ca), protein phosphatase 4 catalytic subunit (PPP4C), protein phosphatase 4, catalytic subunit (Ppp4c), protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S), 1110002D08Rik, AU016079, gc:56413, MGC75928, pp4, PP4, pp4c, PP4C, PP4C-A, pph3, PPH3, PPP4, ppp4c, ppx, PPX, Ppx, wu:fd05e08, zgc:56413Protein level used designations for PPP4C
- protein phosphatase 4, catalytic subunit
- catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit A
- PP-X
- protein phosphatase 4 (formerly X), catalytic subunit
- protein phosphatase X, catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit
- PP4C
- pp4
- protein phosphatase X
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