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PRDM16 Produits

(PR Domain Containing 16 (PRDM16))
The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Catégories PRDM16 en vedette

PRDM16 Anticorps

High quality antibodies with extensive validation data.

PRDM16 Kits ELISA

Reliable ELISA kits for a wide range of species.

PRDM16 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRDM16 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB
Validations
  • (3)
N° du produit ABIN6242535
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7164089
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, ChIP, FACS
Validations
  • (1)
  • (1)
N° du produit ABIN184809
Quantité 100 μg
Fiche technique Fiche technique

PRDM16 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6974822
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958701
Quantité 96 tests
Fiche technique Fiche technique

PRDM16 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3094786
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3130708
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Saccharomyces cerevisiae
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN5710996
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRDM16

Liu, Guan, Wen, Ma, Xu, Hu, Wei, Li, Wang, Xiang, Liao, Ji: "PRDM16 Inhibits Cell Proliferation and Migration via Epithelial-to-Mesenchymal Transition by Directly Targeting Pyruvate Carboxylase in Papillary Thyroid Cancer." dans: Frontiers in cell and developmental biology, Vol. 9, pp. 723777, (2021) (PubMed).

Baskaran, Covington, Bennis, Mohandass, Lehmann, Thyagarajan: "Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin." dans: Molecules (Basel, Switzerland), Vol. 23, Issue 12, (2018) (PubMed).

Baskaran, Krishnan, Ren, Thyagarajan: "Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms." dans: British journal of pharmacology, Vol. 173, Issue 15, pp. 2369-89, (2016) (PubMed).

Stanford, Middelbeek, Townsend, An, Nygaard, Hitchcox, Markan, Nakano, Hirshman, Tseng, Goodyear: "Brown adipose tissue regulates glucose homeostasis and insulin sensitivity." dans: The Journal of clinical investigation, Vol. 123, Issue 1, pp. 215-23, (2013) (PubMed).

Lahortiga, Agirre, Belloni, Vázquez, Larrayoz, Gasparini, Lo Coco, Pelicci, Calasanz, Odero: "Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells." dans: Oncogene, Vol. 23, Issue 1, pp. 311-6, (2004) (PubMed).

Xinh, Tri, Nagao, Nakazato, Taketazu, Fujisawa, Yagasaki, Chen, Hayashi, Toyoda, Hattori, Sakaki, Tokunaga, Sato: "Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1." dans: Genes, chromosomes & cancer, Vol. 36, Issue 3, pp. 313-6, (2003) (PubMed).

Nishikata, Sasaki, Iga, Tateno, Imayoshi, Asou, Nakamura, Morishita: "A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation." dans: Blood, Vol. 102, Issue 9, pp. 3323-32, (2003) (PubMed).

Mochizuki, Shimizu, Nagasawa, Tanaka, Taniwaki, Yokota, Morishita: "A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells." dans: Blood, Vol. 96, Issue 9, pp. 3209-14, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à PRDM16

PR/SET domain 16 (PRDM16), PR domain containing 16 (prdm16), PR domain containing 16 (Prdm16), PR/SET domain 16 (Prdm16), 5730557K01Rik, C130091E20, csp1, MEL1, mel1, mKIAA1675, PFM13, PRDM16, wu:fc09g08

Protein level used designations for PRDM16

  • PR domain containing 16
  • fc09g08
  • PR domain zinc finger protein 16-like
  • MDS1/EVI1-like gene 1
  • PR domain zinc finger protein 16
  • transcription factor MEL1
  • PR domain-containing protein 16
  • line 27
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