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PRDM6 Produits

(PR Domain Containing 6 (PRDM6))

Catégories

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

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Catégories PRDM6 en vedette

PRDM6 Anticorps

High quality antibodies with extensive validation data.

PRDM6 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRDM6 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN6146147
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN6739478
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN928519
Quantité 100 μL
Fiche technique Fiche technique

PRDM6 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3094724
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3135115
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PRDM6

Li, Subrahmanyan, Smith, Yu, Zaidi, Choi, Mane, Nelson-Williams, Bahjati, Kazemi, Hashemi, Fathzadeh, Narayanan, Tian, Montazeri, Mani, Begleiter, Coon, Lynch, Olson, Zhao, Ruland, Lifton, Mani: "Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus." dans: American journal of human genetics, Vol. 98, Issue 6, pp. 1082-91, (2016) (PubMed).

Synonymes et noms alternatifs relatifs à PRDM6

PR/SET domain 6 (PRDM6), PR domain containing 6 (Prdm6), PR/SET domain 6 (Prdm6), putative histone-lysine N-methyltransferase PRDM6 (LOC100354345), PR domain containing 6 (prdm6), Gm92, PRDM6, PRISM, RGD1559594

Protein level used designations for PRDM6

  • PR domain zinc finger protein 6
  • PR domain-containing protein 6
  • PR-domain zinc finger protein 6
  • putative histone-lysine N-methyltransferase PRDM6
  • PR domain-containing protein in smooth muscle
  • PR domain containing 6
  • LOW QUALITY PROTEIN: putative histone-lysine N-methyltransferase PRDM6
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