Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Dernières publications sur nos produits Prekallikrein
Ryu, Gu, Hong, Han, Kim: "The First Case of Congenital Prekallikrein Deficiency in Korea With a Novel Pathogenic Variant (c.1198G>T)." dans: Annals of laboratory medicine, Vol. 39, Issue 2, pp. 229-231, (2019) (PubMed).
Park, Gu, You, Kim, Kim: "Factor XII-mediated contact activation related to poor prognosis in disseminated intravascular coagulation." dans: Thrombosis research, Vol. 138, pp. 103-7, (2016) (PubMed).
Sharma, Al-Shoumer, Matar, Madathil, Al-Moalem: "Altered activities of kininase II, an angiotensin converting enzyme, prekallikrein, and nitric oxide in Kuwaiti patients with type 2 diabetes." dans: International journal of immunopathology and pharmacology, Vol. 28, Issue 2, pp. 240-6, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à Prekallikrein
kallikrein related peptidase 3 (KLK3), APS, hK3, KLK2A1, PSA