Presenilin 1 Produits
(Presenilin 1 (PSEN1))
Catégories
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
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Catégories Presenilin 1 en vedette
Presenilin 1 Anticorps
High quality antibodies with extensive validation data.
Presenilin 1 Kits ELISA
Reliable ELISA kits for a wide range of species.
Presenilin 1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Presenilin 1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN3023160
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC (p), FACS, IF
Validations
- (1)
- (4)
N° du produit
ABIN390169
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7164264
Quantité
100 μg
Fiche technique
Fiche technique
Presenilin 1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6958721
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969495
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958722
Quantité
96 tests
Fiche technique
Fiche technique
Presenilin 1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316518
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7414045
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7412977
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Presenilin 1
: "Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy." dans: Disease models & mechanisms, Vol. 12, Issue 12, (2020) (PubMed).: "Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin." dans: PLoS ONE, Vol. 12, Issue 11, pp. e0188605, (2017) (PubMed).
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." dans: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).
: "Nonsteroidal Anti-inflammatory Drugs: Do They Increase the Risk of Anastomotic Leaks Following Colorectal Operations?" dans: Diseases of the colon and rectum, Vol. 58, Issue 9, pp. 870-7, (2015) (PubMed).
: "Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood." dans: Pediatrics, Vol. 135, Issue 6, pp. 1074-81, (2015) (PubMed).
: "Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 31, pp. 10674-85, (2012) (PubMed).
: "Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity." dans: Cell death & disease, Vol. 3, pp. e389, (2012) (PubMed).
: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).
: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." dans: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
: "Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics." dans: Molecular bioSystems, Vol. 6, Issue 9, pp. 1640-9, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à Presenilin 1
presenilin 1 (psen1), presenilin 1 (PSEN1), presenilin 1 (Psen1), presenilin 1 L homeolog (psen1.L), ad3, AD3, Ad3h, fad, FAD, pre1, PS-1, ps1, PS1, psen, s182, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1Protein level used designations for Presenilin 1
- PS-1
- presenilin-1
- presenilin 1 (Alzheimer disease 3)
- presenilin-1 isoform I-463
- presenilin-1 isoform I-467
- presenilin 1
- presenilin-1-like
- PS-alpha
- presenilin alpha
- presenilin-alpha
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