Presenilin 2 Produits
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Catégories
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
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Catégories Presenilin 2 en vedette
Presenilin 2 Anticorps
High quality antibodies with extensive validation data.
Presenilin 2 Kits ELISA
Reliable ELISA kits for a wide range of species.
Presenilin 2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Presenilin 2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), IHC (fro)
Validations
- (6)
N° du produit
ABIN3032302
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS
Validations
- (4)
- (2)
N° du produit
ABIN1944732
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (3)
N° du produit
ABIN7263725
Quantité
200 μL
Fiche technique
Fiche technique
Presenilin 2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969496
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958724
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rabbit
Analytical Method
Quantitative
Validations
- (1)
N° du produit
ABIN775490
Quantité
96 tests
Fiche technique
Fiche technique
Presenilin 2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316520
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7411894
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Monkey, Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2751153
Quantité
5 applications
Fiche technique
Fiche technique
Dernières publications sur nos produits Presenilin 2
: "Novel MITF targets identified using a two-step DNA microarray strategy." dans: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." dans: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." dans: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." dans: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." dans: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Increased expression of presenilin 2 inhibits protein synthesis." dans: Molecular and cellular neurosciences, Vol. 19, Issue 1, pp. 111-24, (2002) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." dans: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." dans: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." dans: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à Presenilin 2
presenilin 2 (PSEN2), presenilin 2 (Psen2), presenilin 2 (psen2), presenilin 2 S homeolog (psen2.S), presenilin 2 (Alzheimer disease 4) (PSEN2), trefoil factor 1 (Tff1), AD3L, ad3l, AD4, ad4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, ps2, Ps2, PSEN2, Psnl2, PSNL2, STM2, stm2, zf-PS2Protein level used designations for Presenilin 2
- AD3LP
- AD5
- E5-1
- PS-2
- STM-2
- presenilin-2
- PS-beta
- presenilin beta
- presenilin-beta
- presenilin 2 (Alzheimer disease 4)
- protein pS2
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