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PRKACA Produits

(Protein Kinase A, alpha (PRKACA))

Catégories

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Catégories PRKACA en vedette

PRKACA Anticorps

High quality antibodies with extensive validation data.

PRKACA Kits ELISA

Reliable ELISA kits for a wide range of species.

PRKACA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRKACA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p), IF, ICC
Validations
  • (4)
N° du produit ABIN2855997
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN7146598
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
N° du produit ABIN6264236
Quantité 100 μL
Fiche technique Fiche technique

PRKACA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965372
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965371
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965370
Quantité 96 tests
Fiche technique Fiche technique

PRKACA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1316219
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316221
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316223
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRKACA

Garcia-Alvarez, Lu, Yap, Wong, Thevathasan, Lim, Ji, Tan, Mancuso, Tang, Poon, Augustine, Fivaz: "STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs." dans: Molecular biology of the cell, Vol. 26, Issue 6, pp. 1141-59, (2015) (PubMed).

Wang, Zhang, Liang, Zhang, Xu, Zhang, Fuji, Mu, Li, Jiang, Ju, Wang: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." dans: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).

Chen, Tiong, Tsai, Liao, Yang, Youn, Mai, Chang: "Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency." dans: Brain structure & function, (2014) (PubMed).

Brunyanszki, Olah, Coletta, Szczesny, Szabo: "Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress." dans: Molecular pharmacology, Vol. 86, Issue 4, pp. 450-62, (2014) (PubMed).

Beuschlein, Fassnacht, Assié, Calebiro, Stratakis, Osswald, Ronchi, Wieland, Sbiera, Faucz, Schaak, Schmittfull, Schwarzmayr, Barreau, Vezzosi, Rizk-Rabin, Zabel, Szarek, Salpea, Forlino, Vetro et al.: "Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. ..." dans: The New England journal of medicine, Vol. 370, Issue 11, pp. 1019-28, (2014) (PubMed).

Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: "PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group." dans: Tumour biology, Vol. 33, Issue 6, pp. 2289-98, (2012) (PubMed).

Zhu, Wang, Kontrogianni-Konstantopoulos, Konstantopoulos: "Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases." dans: Cell death and differentiation, Vol. 17, Issue 8, pp. 1325-34, (2010) (PubMed).

Barnitz, Wan, Tripuraneni, Bolton, Lenardo: "Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection." dans: Journal of virology, Vol. 84, Issue 13, pp. 6410-24, (2010) (PubMed).

Adachi, Kano, Saido, Murata: "Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 14, Issue 3, pp. 355-69, (2009) (PubMed).

Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: "Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A." dans: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 64, Issue 12, pp. 1221-31, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à PRKACA

protein kinase cAMP-activated catalytic subunit alpha (PRKACA), protein kinase cAMP-activated catalytic subunit alpha (Prkaca), protein kinase, cAMP dependent, catalytic, alpha (Prkaca), cAMP-dependent protein kinase catalytic subunit (kin-1), protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a (prkacaa), Calpha, Cs-PKA, PKA, PKACA, Pkaca, PKCA1, PKCD, zgc:158799

Protein level used designations for PRKACA

  • PKA C-alpha
  • cAMP-dependent protein kinase catalytic subunit alpha
  • protein kinase A catalytic subunit
  • cAMP-dependent protein kinase catalytic subunit C alpha
  • protein kinase A
  • protein kinase, cAMP-dependent, catalytic, alpha
  • C-alpha subunit
  • sperm cAMP-dependent protein kinase catalytic subunit
  • protein kinase A alpha
  • prkaca
  • PKA catalytic subunit alpha
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