PRKAR2B Produits
(Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
Catégories
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008].
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Catégories PRKAR2B en vedette
PRKAR2B Anticorps
High quality antibodies with extensive validation data.
PRKAR2B Kits ELISA
Reliable ELISA kits for a wide range of species.
PRKAR2B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PRKAR2B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, FACS, FM
Validations
- (2)
- (4)
N° du produit
ABIN968875
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB
Validations
- (3)
N° du produit
ABIN391062
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN7269663
Quantité
100 μL
Fiche technique
Fiche technique
PRKAR2B recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6958935
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380428
Quantité
2 x 96 tests
Fiche technique
Fiche technique
PRKAR2B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1316253
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3133700
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2729602
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PRKAR2B
: "Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure through SUR2B/Kir6.1 channel in endothelial cells." dans: Acta pharmacologica Sinica, Vol. 38, Issue 1, pp. 41-55, (2016) (PubMed).: "Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout." dans: The Journal of comparative neurology, Vol. 521, Issue 5, pp. 1119-35, (2013) (PubMed).
: "Bipolar cells of the ground squirrel retina." dans: The Journal of comparative neurology, Vol. 519, Issue 4, pp. 759-74, (2011) (PubMed).
: "Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina." dans: The Journal of comparative neurology, Vol. 519, Issue 3, pp. 433-50, (2011) (PubMed).
: "Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop." dans: The Journal of biological chemistry, Vol. 285, Issue 46, pp. 35910-8, (2010) (PubMed).
: "Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods." dans: The Journal of comparative neurology, Vol. 507, Issue 1, pp. 1087-101, (2008) (PubMed).
: "Type 3a and type 3b OFF cone bipolar cells provide for the alternative rod pathway in the mouse retina." dans: The Journal of comparative neurology, Vol. 502, Issue 6, pp. 1123-37, (2007) (PubMed).
: "Selective modulation of protein kinase A I and II reveals distinct roles in thyroid cell gene expression and growth." dans: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 12, pp. 3196-211, (2006) (PubMed).
: "Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7804-12, (2004) (PubMed).
: "Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 8, pp. 3044-51, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à PRKAR2B
protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog (prkar2b.S), protein kinase cAMP-dependent type II regulatory subunit beta (PRKAR2B), protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B), protein kinase cAMP-dependent type II regulatory subunit beta (prkar2b), protein kinase, cAMP dependent regulatory, type II beta (Prkar2b), protein kinase cAMP-dependent type 2 regulatory subunit beta (Prkar2b), AI451071, AW061005, MGC83177, Pkarb2, PKARIIbeta, PRKAR2, PRKAR2B, RATDNA, RII(beta), RII-BETAProtein level used designations for PRKAR2B
- protein kinase, cAMP-dependent, regulatory, type II, beta
- cAMP-dependent protein kinase, regulatory subunit beta 2
- cAMP-dependent protein kinase type II-beta regulatory subunit-like
- protein kinase, cAMP dependent regulatory, type II beta
- cAMP-dependent protein kinase type II-beta regulatory subunit
- Type II beta regulatory subunit of cAMP-dependent protein kinase
- H_RG363E19.2
- WUGSC:H_RG363E19.2
- cAMP-dependent protein kinase type II-beta regulatory chain
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