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PRKDC Produits

(Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

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Catégories PRKDC en vedette

PRKDC Anticorps

High quality antibodies with extensive validation data.

PRKDC Kits ELISA

Reliable ELISA kits for a wide range of species.

PRKDC Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRKDC recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, WB, IHC, ICC
Validations
  • (2)
  • (5)
N° du produit ABIN969366
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IF, IHC (p)
Validations
  • (1)
  • (5)
N° du produit ABIN519209
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN6241643
Quantité 100 μL
Fiche technique Fiche technique

PRKDC recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958940
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1381086
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1130280
Quantité 96 tests
Fiche technique Fiche technique

PRKDC recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1316293
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7399958
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN5710145
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRKDC

Ugidos, Mena, Baquero, Alloza, Azkargorta, Elortza, Vandenbroeck: "Interactome of the Autoimmune Risk Protein ANKRD55." dans: Frontiers in immunology, Vol. 10, pp. 2067, (2019) (PubMed).

Biehs, Steinlage, Barton, Juhász, Künzel, Spies, Shibata, Jeggo, Löbrich: "DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination." dans: Molecular cell, Vol. 65, Issue 4, pp. 671-684.e5, (2017) (PubMed).

Ha, Ma, Lin, Tang, Lian, Zhao, Li, Zhen, Pei, Han, Malumbres, Jin, Chen, Zhao, Zhu, Zhang: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." dans: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).

Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." dans: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).

Fantini, Huang, Asara, Bagchi, Raychaudhuri: "Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2." dans: Molecular biology of the cell, Vol. 28, Issue 1, pp. 192-200, (2016) (PubMed).

Sun, Cheng, Zhu, Zhang, Liu, Xu, Sun, Lv: "Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells." dans: Gene, Vol. 584, Issue 1, pp. 90-6, (2016) (PubMed).

Berard, Coombs, Severini: "Quantification of the host response proteome after herpes simplex virus type 1 infection." dans: Journal of proteome research, Vol. 14, Issue 5, pp. 2121-42, (2015) (PubMed).

Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: "Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics." dans: Cell death & disease, Vol. 4, pp. e517, (2013) (PubMed).

Schuler, Rübe: "Accumulation of DNA damage-induced chromatin alterations in tissue-specific stem cells: the driving force of aging?" dans: PLoS ONE, Vol. 8, Issue 5, pp. e63932, (2013) (PubMed).

Lorat, Schanz, Schuler, Wennemuth, Rübe, Rübe: "Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy." dans: PLoS ONE, Vol. 7, Issue 5, pp. e38165, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à PRKDC

protein kinase, DNA-activated, catalytic polypeptide (PRKDC), protein kinase, DNA-activated, catalytic polypeptide L homeolog (prkdc.L), DNA-dependent protein kinase catalytic subunit (LOC100633457), protein kinase, DNA activated, catalytic polypeptide (Prkdc), AI326420, AU019811, DNA-PKcs, DNA-PKCS, dna-pkcs, DNAPDcs, DNAPK, dnapk, DNPK1, dnpk1, DOXNPH, dxnph, HYRC, hyrc, HYRC1, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, XRCC7, xrcc7

Protein level used designations for PRKDC

  • DNA-PK catalytic subunit
  • DNA-dependent protein kinase catalytic subunit
  • hyper-radiosensitivity of murine scid mutation, complementing 1
  • p460
  • protein kinase, DNA-activated, catalytic polypeptide
  • DNA-PKcs
  • protein kinase catalytic subunit (DNA-dependent protein kinase)
  • DNA-activated protein kinase catalytic polypeptide
  • DNA-dependent protein kinase catalytic subunit-like
  • doxorubicin nephropathy
  • severe combined immunodeficiency
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