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PRKG1 Produits

(Protein Kinase, CGMP-Dependent, Type I (PRKG1))

Catégories

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011].

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Catégories PRKG1 en vedette

PRKG1 Anticorps

High quality antibodies with extensive validation data.

PRKG1 Kits ELISA

Reliable ELISA kits for a wide range of species.

PRKG1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRKG1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (4)
N° du produit ABIN392536
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN562400
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
N° du produit ABIN562402
Quantité 100 μg
Fiche technique Fiche technique

PRKG1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969729
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958936
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958937
Quantité 96 tests
Fiche technique Fiche technique

PRKG1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316297
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316295
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509120
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRKG1

Schwappacher, Kilic, Kojonazarov, Lang, Diep, Zhuang, Gawlowski, Schermuly, Pfeifer, Boss, Pilz: "A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension." dans: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16557-66, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à PRKG1

protein kinase, cGMP-dependent, type Ia (prkg1a), protein kinase, cGMP-dependent, type I (PRKG1), protein kinase, cGMP-dependent, type I (prkg1), protein kinase, cGMP-dependent, type 1 (Prkg1), protein kinase, cGMP-dependent, type I (Prkg1), 1, AW125416, cGK, cGk1, cGK 1, cGK1, cGKI, CGKI, cGKI-alpha, cGKI-BETA, cGKI-beta, Gm19690, PKG, Pkgi, prkg1, PRKG1B, Prkg1b, Prkg1beta, PRKGR1B, Prkgr1b, zgc:63955

Protein level used designations for PRKG1

  • cGMP-dependent protein kinase 1
  • protein kinase, cGMP-dependent, type I
  • cGMP-dependent protein kinase 1, beta isozyme
  • cGMP-dependent protein kinase I alpha
  • cGK I alpha
  • cGMP-dependent protein kinase 1-like
  • cGMP dependent protein kinase type 1
  • protein kinase, cGMP-dependent, regulatory, type I, beta
  • CGK 1 alpha
  • cGK 1 beta
  • cGK1
  • cGKI-alpha
  • cGMP-dependent protein kinase 1, alpha isozyme
  • cGMP-dependent protein kinase I
  • cGK 1
  • PKG1 alpha
  • cGMP-dependent protein kinase type 1 alpha
  • cGMP-dependent protein kinase type I beta
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