Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PRMT5 Produits

(Protein Arginine Methyltransferase 5 (PRMT5))

Catégories

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories PRMT5 en vedette

PRMT5 Anticorps

High quality antibodies with extensive validation data.

PRMT5 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRMT5 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (8)
N° du produit ABIN3022066
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (4)
N° du produit ABIN6266359
Quantité 100 μL
Fiche technique Fiche technique

Application WB, IHC, IHC (p)
Validations
  • (3)
N° du produit ABIN203229
Quantité 100 μL
Fiche technique Fiche technique

PRMT5 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6211653
Quantité 96 tests
Fiche technique Fiche technique

PRMT5 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1316333
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316335
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Baculovirus
Validations
  • (2)
N° du produit ABIN2669658
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRMT5

Pak, Lee, Roh: "High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma." dans: Pathology international, Vol. 65, Issue 10, pp. 541-8, (2015) (PubMed).

Yang, Wang, Ren, Jin, Wang, Sun, Diao, Wang, Mi: "Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression." dans: Tumour biology, Vol. 36, Issue 8, pp. 5901-11, (2015) (PubMed).

Ratovitski, Arbez, Stewart, Chighladze, Ross: "PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)." dans: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 11, pp. 1716-29, (2015) (PubMed).

Kanamaluru, Xiao, Fang, Choi, Kim, Veenstra, Kemper: "Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner." dans: Molecular and cellular biology, Vol. 31, Issue 7, pp. 1540-50, (2011) (PubMed).

Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." dans: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).

Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: "PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing." dans: Nature structural & molecular biology, Vol. 16, Issue 3, pp. 304-11, (2009) (PubMed).

Pal, Yun, Datta, Lacomis, Erdjument-Bromage, Kumar, Tempst, Sif: "mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad." dans: Molecular and cellular biology, Vol. 23, Issue 21, pp. 7475-87, (2003) (PubMed).

Rho, Choi, Seong, Cho, Kim, Im: "Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family." dans: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 11393-401, (2001) (PubMed).

Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: "Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14781-6, (1999) (PubMed).

Pollack, Kotenko, He, Izotova, Barnoski, Pestka: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." dans: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à PRMT5

protein arginine methyltransferase 5 (PRMT5), protein arginine N-methyltransferase 5 (Prmt5), protein arginine methyltransferase 5 (Prmt5), protein arginine methyltransferase 5 (prmt5), protein arginine methyltransferase 5 L homeolog (prmt5.L), putative arginine N-methyltransferase, type II (PRMT5), Skb1 family protein (prmt5), protein arginine N-methyltransferase 5 (LOC100115766), Protein arginine N-methyltransferase 5 (prmt-5), DDBDRAFT_0187422, DDBDRAFT_0235403, DDB_0187422, DDB_0235403, HRMT1L5, hrmt1l5, hsl7, IBP72, ibp72, JBP1, Jbp1, jbp1, NV18830, si:zc14a17.2, SKB1, Skb1, skb1, SKB1Hs, skb1hs, wu:fb95f10, zgc:110669

Protein level used designations for PRMT5

  • 72 kDa ICln-binding protein
  • HMT1 hnRNP methyltransferase-like 5
  • SKB1 homolog
  • histone-arginine N-methyltransferase PRMT5
  • jak-binding protein 1
  • protein arginine N-methyltransferase 5
  • shk1 kinase-binding protein 1 homolog
  • protein arginine methyltransferase 5
  • Jak-binding protein 1
  • putative arginine N-methyltransferase, type II
  • protein arginine methyltransferase
  • protein arginine N-methyltransferase 5-like
Vous êtes ici:
Support technique