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PRNP Produits

(Prion Protein (PRNP))
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

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Catégories PRNP en vedette

PRNP Anticorps

High quality antibodies with extensive validation data.

PRNP Kits ELISA

Reliable ELISA kits for a wide range of species.

PRNP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PRNP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7433921
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, FACS
Validations
  • (4)
N° du produit ABIN7193415
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
N° du produit ABIN7260569
Quantité 200 μL
Fiche technique Fiche technique

PRNP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969500
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969499
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958725
Quantité 96 tests
Fiche technique Fiche technique

PRNP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7275480
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7275481
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316351
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PRNP

Goetzl, Elahi, Mustapic, Kapogiannis, Pryhoda, Gilmore, Gorgens, Davidson, Granholm, Ledreux: "Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 4, pp. 5082-5088, (2020) (PubMed).

Hu, Li, You, Zhang, Jin, Huang: "Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment." dans: Journal of integrative neuroscience, Vol. 18, Issue 4, pp. 439-444, (2020) (PubMed).

Cook, Bingham, Besier, Bayley, Hawes, Shearer, Yamada, Bergfeld, Williams, Middleton: "Atypical scrapie in Australia." dans: Australian veterinary journal, Vol. 94, Issue 12, pp. 452-455, (2016) (PubMed).

Reil, Bux: "Geno- and phenotyping of human neutrophil antigens." dans: Methods in molecular biology (Clifton, N.J.), Vol. 1310, pp. 193-203, (2016) (PubMed).

Ortiz-Pelaez, Georgiadou, Simmons, Windl, Dawson, Arnold, Neocleous, Papasavva-Stylianou: "Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats." dans: Epidemiology and infection, Vol. 143, Issue 6, pp. 1304-10, (2015) (PubMed).

Wang, Tian, Fan, Chen, Lv, Sun, Zhao, Zhang, Wang, Shi, Gao, Chen, Shao, Dong: "Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction." dans: The international journal of biochemistry & cell biology, Vol. 62, pp. 24-35, (2015) (PubMed).

Risse, Nicoll, Taylor, Wright, Badoni, Yang, Farrow, Collinge: "Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay." dans: The Journal of biological chemistry, Vol. 290, Issue 27, pp. 17020-8, (2015) (PubMed).

Richardson, Tol, Valle-Encinas, Pleguezuelos, Bierings, Geerts, Fernandez-Borja: "The prion protein inhibits monocytic cell migration by stimulating β1 integrin adhesion and uropod formation." dans: Journal of cell science, Vol. 128, Issue 16, pp. 3018-29, (2015) (PubMed).

Dvorakova, Vranac, Janouskova, ?ernilec, Koren, Lukan, Nováková, Matej, Holada, ?urin Šerbec: "Detection of the GPI-anchorless prion protein fragment PrP226* in human brain." dans: BMC neurology, Vol. 13, pp. 126, (2013) (PubMed).

Mercer, Ma, Watts, Strome, Wohlgemuth, Yang, Cashman, Coulthart, Schmitt-Ulms, Jhamandas, Westaway: "The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37241-55, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à PRNP

prion protein (PRNP), prion protein (Prnp), prion protein S homeolog (prnp.S), prion protein b (prnpb), AA960666, AI325101, AltPrP, ASCR, CD230, CJD, cjd, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, prnprs1, PrP, prp, PRP, Prp, prp(c), PrP-1, PrP1, PrP27-30, prP27-30, PrP33-35C, prP33-35C, PrP, PrPc, PRPC, PrPC, PrPSc, Sinc, SIP, stPrP-1, zgc:123004

Protein level used designations for PRNP

  • CD230 antigen
  • major prion protein
  • prion-related protein
  • prion protein, PrP
  • prion protein, structural
  • major scrapie-associated fibril protein 1
  • prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
  • prion protein PrP
  • prion protein precursor PrP
  • prion protein variant a
  • prion protein variant b
  • 65-21 protein
  • ARIA
  • PR-LP
  • acetylcholine receptor-inducing activity
  • major prion protein homolog
  • prion-like protein
  • prion-like-protein
  • prion protein
  • infectious amyloid
  • Major prion protein
  • major prion protein preproprotein
  • prP
  • prP27-30
  • prP33-35C
  • PrP 27-30
  • prion protein 1
  • prion protein b
  • prion protein, related sequence 1
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