recombinant Tissue Factor comprises a 219 amino acid fragment (33-251) corresponding to the extracellular domain of Tissue Factor protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
F3
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Tissue factor is best known as the primary cellular initiator of blood coagulation. After vessel injury, the Tissue Factor : Factor VIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. In addition, aberrant Tissue Factor expression within the vasculature initiates life-threatening thrombosis in various diseases, such as sepsis, atherosclerosis, and cancer.,Coagulation Factor III, TF, Tissue Thromboplastin, CD142