PODXL Protein (AA 32-458, partial) (His tag)

N° du produit ABIN1095725

Détail du produit

Antigène: PODXL (Podocalyxin-Like (PODXL))

Type de proteíne: Recombinant

Attributs du protein: AA 32-458, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PODXL protéine est marqué à la His tag.

Application: SDS-PAGE (SDS), ELISA

Séquence: QNATQTTTDS SNKTAPTPAS SVTIMATDTA QQSTVPTSKA NEILASVKAT TLGVSSDSPG TTTLAQQVSG PVNTTVARGG GSGNPTTTIE SPKSTKSADT TTVATSTATA KPNTTSSQNG AEDTTNSGGK SSHSVTTDLT STKAEHLTTP HPTSPLSPRQ PTSTHPVATP TSSGHDHLMK ISSSSSTVAI PGYTFTSPGM TTTLLETVFH HVSQAGLELL TSGDLPTLAS QSAGITASSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRF

Attributs du produit: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Pureté: 90 %

Information d'application

Commentaires:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole

Stock: -20 °C

Détail du antigène

Antigène: PODXL (Podocalyxin-Like (PODXL))

Autre désignation: Podocalyxin (PODXL Produits)

Synonymes: Gp200 Protein, PC Protein, PCLP Protein, PCLP-1 Protein, PCB Protein, AW121214 Protein, Ly102 Protein, Pclp1 Protein, podocalyxin Protein, MEP21 Protein, PODXL Protein, Gp135 Protein, PCLP1 Protein, cPCLP1 Protein, podxl Protein, fc18d02 Protein, wu:fc18d02 Protein, Pc Protein, Pcb Protein, Podxl Protein, podocalyxin like Protein, pyruvate carboxylase Protein, podocalyxin-like Protein, PODXL Protein, PC Protein, Podxl Protein, podxl Protein, Pcx Protein

Sujet: Synonyms: GCTM-2 antigen Gp200 Podocalyxin-like protein 1 Short name=PC Short name=PCLP-1

Poids moléculaire: 48.3 kD

UniProt: O00592

Pathways: Tube Formation