IL1F9 Protein (AA 13-164)

N° du produit ABIN1343990

Détail du produit

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 13-164

Origine: Souris

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse IL-36gamma (aa Gly13-Ser164) is untagged.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Induces secretion of IL-6 in BMDCs.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS + 0.5 % Trehalose.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Autre désignation: IL-36 gamma (IL1F9 Produits)

Synonymes: IL-1F9 Protein, IL-1H1 Protein, IL-1RP2 Protein, IL1E Protein, IL1F9 Protein, IL1H1 Protein, IL1RP2 Protein, Il36g Protein, Il1f9 Protein, RGD1563019 Protein, IL36G Protein, interleukin 36 gamma Protein, interleukin 1 family, member 9 Protein, interleukin 36, gamma Protein, interleukin-36 gamma Protein, IL36G Protein, Il1f9 Protein, Il36g Protein, LOC100065031 Protein

Sujet: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.

Poids moléculaire: ~17kDa

UniProt: Q8R460