FIL1d Protein (AA 3-156)

N° du produit ABIN1343995

Détail du produit

Antigène: FIL1d (Interleukin 1 delta (FIL1d))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 3-156

Origine: Souris

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Mouse IL36Ra (aa Val3-Asp156) is untagged.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.05EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1μg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: FIL1d (Interleukin 1 delta (FIL1d))

Autre désignation: IL-36Ra (FIL1d Produits)

Synonymes: AI413231 Protein, Fil1delta Protein, IL36RN Protein, Il-1h3 Protein, Il1hy1 Protein, FIL1 Protein, FIL1(DELTA) Protein, FIL1D Protein, IL1F5 Protein, IL1HY1 Protein, IL1L1 Protein, IL1RP3 Protein, IL36RA Protein, PSORP Protein, Il1f5 Protein, interleukin 1 family, member 5 (delta) Protein, interleukin 36 receptor antagonist Protein, Il1f5 Protein, IL36RN Protein, Il36rn Protein

Sujet: IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

Poids moléculaire: ~17kDa

UniProt: Q9QYY1