Calreticulin Protein (CALR) (His tag)
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- Antigène Voir toutes Calreticulin (CALR) Protéines
- Calreticulin (CALR)
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette Calreticulin protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Réactivité croisée
- Humain
- Attributs du produit
- Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.
- Pureté
- >90 % (SDS-PAGE)
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- <1EU/μg purified protein (LAL test, Lonza).
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - Date de péremption
- 3 months
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- Antigène
- Calreticulin (CALR)
- Autre désignation
- Calreticulin (CALR Produits)
- Sujet
- Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the 'calreticulin/calnexin cycle' that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
- Poids moléculaire
- ~55kDa (SDS-PAGE)
- UniProt
- P27797
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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