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TNFRSF12A Protein (AA 28-75) (Fc Tag)
TNFRSF12A
Origine: Humain, Souris
Hôte: HEK-293 Cells
Recombinant
>95 % (SDS-PAGE)
SDS
N° du produit ABIN1344155
Détail du produit
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Antigène
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TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Type de proteíne
Recombinant
Attributs du protein
AA 28-75
Origine
Humain, Souris
Source
Toutes les sources à travers TNFRSF12A Protéines
HEK-293 Cells
Purification/Conjugué
Cette TNFRSF12A protéine est marqué à la Fc Tag.
Application
SDS-PAGE (SDS)
Specificité
Binds to mouse and human TWEAK.
Réactivité croisée
Humain, Souris
Attributs du produit
The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.
Pureté
>95 % (SDS-PAGE)
niveau d'endotoxine
<0.1EU/μg purified protein (LAL test, Lonza).
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Lyophilized
Reconstitution
Reconstitute with 50 μL sterile water.
Concentration
Lot specific
Buffer
Lyophilized. Contains PBS.
Stock
4 °C,-20 °C
Stockage commentaire
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.
Date de péremption
6 months
Détail du antigène
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Antigène
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Autre désignation
Fn14 (TNFRSF12A Produits )
Synonymes
CD266 Protein, FN14 Protein, TWEAKR Protein, AI255180 Protein, C87282 Protein, Fn14 Protein, HPIP Protein, TWEAK-R Protein, TweakR Protein, TNF receptor superfamily member 12A Protein, tumor necrosis factor receptor superfamily, member 12a Protein, TNFRSF12A Protein, Tnfrsf12a Protein
Sujet
TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
Poids moléculaire
~35kDa (SDS-PAGE).
UniProt
Q9NP84
Pathways
Apoptose , Regulation of Cell Size
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