NOTCH2 Protein (AA 26-494, Extracellular Domain) (Fc Tag)
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- Antigène Voir toutes NOTCH2 Protéines
- NOTCH2 (Notch 2 (NOTCH2))
- Type de proteíne
- Recombinant
- Attributs du protein
- Extracellular Domain, AA 26-494
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Origine
- Souris
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Source
- CHO Cells
- Purification/Conjugué
- Cette NOTCH2 protéine est marqué à la Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificité
- Binds to mouse DLL1 and DLL4.
- Réactivité croisée
- Souris
- Attributs du produit
- The extracellular domain of mouse Notch2 (aa 26-494) (12 epidermal growth factor-like (EGF) repeats) is fused at the C-terminus to the Fc portion of human IgG1.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product NOTCH2 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Date de péremption
- 6 months
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Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7212-22, (2009) (PubMed).
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Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7212-22, (2009) (PubMed).
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- Antigène
- NOTCH2 (Notch 2 (NOTCH2))
- Autre désignation
- Notch2 (NOTCH2 Produits)
- Synonymes
- AGS2 Protein, HJCYS Protein, hN2 Protein, AI853703 Protein, N2 Protein, notch6 Protein, sb:cb884 Protein, neurogenic locus notch homolog protein 2 Protein, notch 2 Protein, notch 3 Protein, LOC581186 Protein, NOTCH2 Protein, notch3 Protein, Notch2 Protein, notch2 Protein
- Sujet
- Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
- Poids moléculaire
- ~87kDa (SDS-PAGE)
- UniProt
- O35516
- Pathways
- Signalisation Notch, Stem Cell Maintenance
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