TNFSF18 Protein (AA 45-173, Extracellular Domain, Soluble) (DYKDDDDK Tag)
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- Antigène Voir toutes TNFSF18 Protéines
- TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- Soluble, Extracellular Domain, AA 45-173
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TNFSF18 protéine est marqué à la DYKDDDDK Tag.
- Application
- SDS-PAGE (SDS)
- Specificité
- Binds to mouse GITR.
- Réactivité croisée
- Souris
- Attributs du produit
- The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
- Pureté
- >90 % (SDS-PAGE)
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFSF18 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in 10 mM glycine, pH 10.0.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - Date de péremption
- 3 months
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- Antigène
- TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
- Autre désignation
- GITRL (TNFSF18 Produits)
- Synonymes
- Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein
- Sujet
- GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
- Poids moléculaire
- ~22kDa (SDS-PAGE)
- UniProt
- Q7TS55
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