Annexin V Protein (GST tag)

N° du produit ABIN1344454

Détail du produit

Antigène: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Annexin V protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Specificité: Binds to phosphatidylserine (PS).

Réactivité croisée: Humain

Attributs du produit: Recombinant human annexin V fused to a GST-tag.

Pureté: >95 % (SDS-PAGE)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. In PBS, pH 7.4.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C.

Date de péremption: 12 months

Référence

Morizono, Chen: "Role of phosphatidylserine receptors in enveloped virus infection." dans: Journal of virology, Vol. 88, Issue 8, pp. 4275-90, (2014) (PubMed).

Détail du antigène

Antigène: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Autre désignation: Annexin V (ANXA5 Produits)

Synonymes: anx Protein, anx5 Protein, ANX V Protein, anxa5 Protein, cb989 Protein, wu:fa98f06 Protein, wu:fj10f10 Protein, MGC89158 Protein, ANX5 Protein, ENX2 Protein, PP4 Protein, RPRGL3 Protein, Anx5 Protein, R74653 Protein, LC5 Protein, enx2 Protein, annexin A5 Protein, annexin A5b Protein, Annexin A5 Protein, annexin A5 L homeolog Protein, ANXA5 Protein, anxa5b Protein, anxa5 Protein, Anxa5 Protein, anxa5.L Protein

Sujet: Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Poids moléculaire: ~52kDa (SDS-PAGE)

UniProt: P08758

Pathways: Apoptose