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Flagellin Protein (FliC)

FliC Origine: Humain, Souris Hôte: Salmonella typhimurium Recombinant >95 % (SDS-PAGE) SDS Active
N° du produit ABIN1344458
  • Antigène Voir toutes Flagellin (FliC) Protéines
    Flagellin (FliC)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Source
    • 7
    • 5
    • 1
    Salmonella typhimurium
    Application
    SDS-PAGE (SDS)
    Specificité
    Binds to human and mouse TLR5 (Toll-like receptor 5).
     Réactivité croisée
    Humain, Souris
    Pureté
    >95 % (SDS-PAGE)
    niveau d'endotoxine
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product FliC Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin (high Purity) at a concentration of 5-50ng /ml and in vivo at a starting concentration of 0.1-1μg /mouse.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with 100 μL sterile water.
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Date de péremption
    6 months
  • Antigène
    Flagellin (FliC)
    Autre désignation
    Flagellin (FliC Produits)
    Synonymes
    hag Protein, flaG Protein, flagellin Protein, flagellin (flic) Protein, flagellin E Protein, flagellin protein flic Protein, fliC Protein, FliC Protein, fliC+F2048 Protein, CJJ81176_1339 Protein, C8J_1256 Protein
    Classe de substances
    Tag
    Sujet
    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
    UniProt
    P06179
    Pathways
    Inflammasome
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