FGFR2 Protein (Dimer, glycosylated, Soluble) (Fc Tag)
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- Antigène Voir toutes FGFR2 Protéines
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- Dimer, glycosylated, Soluble
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Origine
- Humain
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Source
- Cellules d'insectes
- Purification/Conjugué
- Cette FGFR2 protéine est marqué à la Fc Tag.
- Fonction
- FGFR-2(IIIc)/Fc Chimera, soluble
- Séquence
- RPSFSLVEDT TLEPEEPPTK YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD SGLYACTASR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNNK RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA GGNPMPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT CLAGNSIGIS FHSAWLTVLP APGREKEITA SPDYLEDPRR ASIEGRGDPE EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
- Specificité
- Chromosomal location:10q26
- Attributs du produit
- Length (aa):602
- Pureté
- > 90 % by SDS-PAGE
- Top Product
- Discover our top product FGFR2 Protéine
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- Indications d'application
- Determined by its ability to inhibit human FGF basic-dependent proliferation on HUVE cells. The ED50 for this effect is typically at 15 - 30 ng/mL.
- Commentaires
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Soluble Receptors
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- The lyophilized sFGFR-2/Fc is soluble in water and most aqueous buffers and should be reconstituted in PBS or medium to a concentration not lower than 50 μg/mL.
- Buffer
- PBS
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted sFGFR-2/Fc should be stored in working aliquots at -20°C.
- Date de péremption
- 6 months
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- Antigène
- FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))
- Autre désignation
- FGFR-2 (FGFR2 Produits)
- Synonymes
- FGFR2 Protein, FGFR2IIIb Protein, bek Protein, bfr-1 Protein, cd332 Protein, cek3 Protein, cfd1 Protein, ect1 Protein, fgfr-2 Protein, jws Protein, k-sam Protein, kgfr Protein, tk14 Protein, tk25 Protein, xfgfr2 Protein, DKFZp469H1521 Protein, BBDS Protein, BEK Protein, BFR-1 Protein, CD332 Protein, CEK3 Protein, CFD1 Protein, ECT1 Protein, JWS Protein, K-SAM Protein, KGFR Protein, TK14 Protein, TK25 Protein, AU043015 Protein, AW556123 Protein, Bek Protein, Fgfr-2 Protein, Fgfr-7 Protein, Fgfr7 Protein, KGFRTr Protein, svs Protein, FGF-R Protein, fgfr72IIIb Protein, FGFR Protein, fc56c05 Protein, wu:fc56c05 Protein, fibroblast growth factor receptor 2 Protein, fibroblast growth factor receptor 2 L homeolog Protein, FGFR2 Protein, LOC100084641 Protein, fgfr2 Protein, Fgfr2 Protein, fgfr2.L Protein
- Sujet
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Recombinant human soluble FGFR-2 alpha (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-2 alpha (IIIc) is a disulfide-linked heterodimeric protein. In the reduced form the glycosylated subunits of sFGFR-2 alpha/human Fc chimera display a molecular mass of 80-85 kDa. Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the ß isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.
Synonyms: FGFR2, BEK, JWS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAM - Poids moléculaire
- 67.1 kDa
- ID gène
- 2263
- NCBI Accession
- NM_000141, NP_000132
- UniProt
- P21802
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding
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